Home/Academic Papers/Papers i owe my pipettes/The Mutational Constraint Spectrum Quantified from Variation in 141,456 Humans1 / 1ItemThe Mutational Constraint Spectrum Quantified from Variation in 141,456 Humansin Papers i owe my pipettes by Priya Nair0likesLike this itemFollow Priya NairOpen in appThe Mutational Constraint Spectrum Quantified from Variation in 141,456 Humans on “Papers i owe my pipettes”, a list by Priya Nair on TheLysts.DetailsPhoto—Name—FieldHuman genetics / gnomADWhat it’s aboutKarczewski et al. aggregating exomes and genomes in gnomAD to quantify which genes tolerate loss-of-function, and which absolutely do not.My takemy moral compass when i’m tempted to call a variant “probably fine.” spoiler: it usually isn’t.PreviousHighly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter DropletsNextMillisecond-timescale, Genetically Targeted Optical Control of Neural ActivityRelated itemsRevisiting The HallmarksThe CRASH-2 trial collaborators. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patientsRivers E. Early goal-directed therapy in the treatment of severe sepsis and septic shockGlobal Burden of Disease 2019Report
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