Marshall & Warren, Unidentified Curved Bacilli in the Stomach on “Papers that actually changed stuff”, a list by Callum Ogden on TheLysts.
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Marshall literally necked the bacteria himself to prove his point, that's dedication or madness I can't decide which. Won him a Nobel though so fair enough
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Unidentified Curved Bacilli in the Stomach of Patients with Gastritis and Peptic Ulceration